Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.67 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.67 |
| ▸ | CLK1 | P49759 | 1/20 | 0.67 |
| ▸ | CLK2 | P49760 | 1/20 | 0.67 |
| ▸ | CLK3 | P49761 | 1/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.50 |
| ▸ | TTK | P33981 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21738302 | 0.91 | DYRK1A (0.81) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21738330 | 0.90 | DYRK1A (0.79) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21738303 | 0.88 | DYRK1A (0.62) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21738260 | 0.87 | TTK (0.59) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL24288501 | 0.83 | DYRK1A (0.50) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL29397365 | 0.83 | DYRK1A (0.50) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL22233438 | 0.83 | DYRK1A (0.50) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL29400524 | 0.83 | DYRK1A (0.50) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL22233488 | 0.83 | DYRK1A (0.49) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL25107631 | 0.82 | DYRK1A (0.67) | DYRK1ADYRK3CSNK1ECLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | disclosed |