Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | SETD2 | Q9BYW2 | 19/20 | 0.51 |
| ▸ | NSD2 | O96028 | 4/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21739280 | 0.86 | HRH4 (0.56) | HRH4SETD2NSD2CYP2C8DRD2 | |
| SCHEMBL25039711 | 0.86 | HRH4 (0.56) | HRH4SETD2NSD2CYP2C8DRD2 | |
| SCHEMBL21725077 | 0.81 | HRH4 (0.59) | HRH4SETD2NSD2 | |
| SCHEMBL30056140 | 0.81 | HRH4 (0.59) | HRH4SETD2NSD2 | |
| SCHEMBL21724765 | 0.80 | HRH4 (0.58) | HRH4SETD2NSD2CYP2C8DRD2 | |
| SCHEMBL25040426 | 0.79 | SETD2 (0.60) | HRH4SETD2NSD2CYP2C8DRD2 | |
| SCHEMBL26097856 | 0.79 | SETD2 (0.60) | HRH4SETD2NSD2CYP2C8DRD2 | |
| SCHEMBL25039576 | 0.75 | SETD2 (0.53) | SETD2NSD2CYP2D6 | |
| SCHEMBL25039473 | 0.75 | SETD2 (0.67) | HRH4SETD2NSD2 | |
| SCHEMBL21724772 | 0.75 | HRH4 (0.53) | HRH4SETD2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261243-A1 | COMBINATION THERAPIES WITH SETD2 INHIBITORS | Epizyme, Inc. (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2020037079-A1 | SUBSTITUTED INDOLES AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |