SCHEMBL21741929

SCHEMBL21741929

N#Cc1ccc(-c2nc(-c3ccccc3)nc(-c3ccc(C#N)cc3-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)n2)c(-n2c3ccc(-c4ccccc4)cc3c3cc(-c4ccccc4)ccc32)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 10/20 0.40
ABCB1 P08183 4/20 0.40
MEN1 O00255 3/20 0.38
ALDH1A1 P00352 3/20 0.38
CYP1A2 P05177 3/20 0.38
KMT2A Q03164 3/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2C19 P33261 2/20 0.38
CLK4 Q9HAZ1 2/20 0.38
LMNA P02545 2/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
ALDH1A3 P47895 2/20 0.36
ABCC1 P33527 1/20 0.36
CYP19A1 P11511 1/20 0.36
MAPK1 P28482 1/20 0.36
CSNK1A1 P48729 1/20 0.36
CSNK1D P48730 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20114544 1.00 ABCG2 (0.40) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL20114555 0.99 ABCG2 (0.41) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL27016016 0.98 ABCG2 (0.41) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL27016021 0.97 ABCG2 (0.40) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL21742003 0.97 PTGER4 (0.39) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL20114541 0.97 PTGER4 (0.39) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL20114634 0.96 CYP1A2 (0.41) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL27020079 0.96 CYP1A2 (0.42) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL20114571 0.96 PTGER4 (0.40) ABCG2ABCB1MEN1ALDH1A1CYP1A2
SCHEMBL20114688 0.95 CYP1A2 (0.44) ABCG2ABCB1MEN1ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020035495-A1 ORGANIC MOLECULES FOR OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-02-20 WO disclosed