Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.49 |
| ▸ | PARP3 | Q9Y6F1 | 5/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422522 | 1.00 | PARP1 (0.50) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL1421860 | 0.91 | PARP1 (0.61) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL5016308 | 0.91 | PARP1 (0.61) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL23854758 | 0.90 | PARP1 (0.61) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL1421856 | 0.90 | PARP1 (0.61) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL28614035 | 0.90 | PARP1 (0.52) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL15777224 | 0.90 | PARP1 (0.49) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL15777226 | 0.90 | PARP1 (0.49) | PARP1PARP2PARP3TNKSCHRM2 | |
| Lithium Ion SCHEMBL29393507 | 0.90 | PARP1 (0.50) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL28677563 | 0.87 | PARP1 (0.44) | PARP1PARP2PARP3TNKSCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025017711-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF NIRAPARIB TOSYLATE MONOHYDRATE | NATCO PHARMA LIMITED (IN) | 2025-01-23 | — | — | WO | disclosed |
| CN-118271233-A | Nilaparil manufacturing method | 特沙诺有限公司 | 2024-07-02 | — | — | CN | disclosed |
| US-11629137-B2 | Methods of manufacturing of niraparib | TESARO, INC. (US) | 2023-04-18 | — | — | US | disclosed |
| EP-3615513-B1 | METHODS OF MANUFACTURING OF NIRAPARIB | TESARO INC (US) | 2022-07-20 | — | — | EP | disclosed |
| US-20220041575-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | TESARO, INC. | 2022-02-10 | — | — | US | disclosed |
| US-11161834-B2 | Methods of manufacturing of niraparib | TESARO, INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20200055837-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | TESARO, INC. | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055837-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | PARP2, PARP1, PARP3 | PARP1 2/4885PARP2 1/4885PARP3 3/4885 |
| US-20220041575-A1 | METHODS OF MANUFACTURING OF NIRAPARIB | PARP2, PARP1, PARP3 | PARP1 2/4885PARP2 1/4885PARP3 3/4885 |
| US-11161834-B2 | Methods of manufacturing of niraparib | PARP2, PARP1, PARP3 | PARP1 2/4885PARP2 1/4885PARP3 3/4885 |
| US-11629137-B2 | Methods of manufacturing of niraparib | PARP2, PARP1, PARP3 | PARP1 2/4885PARP2 1/4885PARP3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.