Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.71 |
| ▸ | RET | P07949 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21744575 | 0.88 | KDM4E (0.66) | IGF1RRETKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL18789263 | 0.77 | RET (0.53) | IGF1RRETAURKAAURKB | |
| SCHEMBL3812064 | 0.77 | RET (0.60) | IGF1RRETHSD17B10GAATSHR | |
| SCHEMBL10093441 | 0.75 | KDM4E (0.65) | RETKDM4EHSD17B10ALDH1A1GAA | |
| SCHEMBL10093442 | 0.75 | KDM4E (0.65) | RETKDM4EHSD17B10ALDH1A1GAA | |
| SCHEMBL28609290 | 0.74 | RET (0.59) | RETAURKAAURKB | |
| SCHEMBL18789284 | 0.74 | IGF1R (0.46) | IGF1RRETAURKAAURKB | |
| SCHEMBL10060058 | 0.73 | RET (0.56) | IGF1RRETHSD17B10GAATSHR | |
| SCHEMBL10060060 | 0.73 | RET (0.56) | IGF1RRETAURKAAURKB | |
| SCHEMBL22534392 | 0.73 | RET (0.53) | RETKDM4EHSD17B10ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035065-A1 | PYRAZOLE DERIVATIVE AS RET INHIBITOR | 南京明德新药研发有限公司 | 2020-02-20 | — | — | WO | disclosed |