SCHEMBL21747641

SCHEMBL21747641

COC(=O)NCC(Oc1ccc(N2CCN(C)c3nc(SC)ncc3C2=O)cc1)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 20/20 0.65
CACNA2D1 P54289 19/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21747618 0.93 CACNA2D1 (0.76) SLC6A2CACNA2D1
SCHEMBL21747628 0.88 CACNA2D1 (0.75) SLC6A2CACNA2D1
SCHEMBL19552946 0.87 CACNA2D1 (0.78) SLC6A2CACNA2D1
SCHEMBL19564576 0.86 CACNA2D1 (0.72) SLC6A2CACNA2D1
SCHEMBL19553003 0.86 SLC6A2 (0.83) SLC6A2CACNA2D1
SCHEMBL21747640 0.85 CACNA2D1 (0.64) SLC6A2CACNA2D1
SCHEMBL19553581 0.85 SLC6A2 (0.85) SLC6A2CACNA2D1
SCHEMBL21747609 0.84 SLC6A2 (0.76) SLC6A2CACNA2D1
SCHEMBL19553078 0.84 CACNA2D1 (0.64) SLC6A2CACNA2D1
SCHEMBL19553272 0.83 CACNA2D1 (0.85) SLC6A2CACNA2D1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3452475-B1 TETRAHYDROPYRIMIDODIAZEPINE AND TETRAHYDROPYRIDODIAZEPINE COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS ESTEVE PHARMACEUTICALS SA (ES) 2020-02-26 EP claimed