Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19370778 | 0.98 | TSHR (0.40) | TSHRCYP3A4TDP1MAPTAPEX1 | |
| SCHEMBL84385 | 0.98 | TSHR (0.40) | TSHRCYP3A4TDP1MAPTAPEX1 | |
| Hydrochloric Acid SCHEMBL27139533 | 0.96 | TSHR (0.39) | TSHRCYP3A4TDP1MAPTAPEX1 | |
| Trifluoroacetic Acid SCHEMBL4779929 | 0.82 | BACE1 (0.34) | TSHRCYP3A4TDP1MAPTAPEX1 | |
| Bromide SCHEMBL28335772 | 0.77 | CYP19A1 (0.44) | TSHRMAPTCYP19A1KMT2A | |
| SCHEMBL12898200 | 0.77 | IL1RN (0.31) | SRD5A1 | |
| SCHEMBL9906479 | 0.75 | — | — | |
| SCHEMBL5178410 | 0.75 | — | — | |
| SCHEMBL19604096 | 0.73 | CYP3A4 (0.41) | TSHRCYP3A4TDP1MAPTAPEX1 | |
| SCHEMBL8556280 | 0.73 | PIK3CD (0.35) | TSHRMAPTCYP19A1KMT2ACRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309649-A1 | SUBSTITUTED GLUTARIMIDE DERIVATIVES | BASF SE (DE) | 2021-10-07 | — | — | US | disclosed |
| EP-3841099-A1 | SUBSTITUTED GLUTARIMIDE DERIVATIVES | BASF SE (DE) | 2021-06-30 | — | — | EP | disclosed |
| CN-112585133-A | Substituted glutarimide derivatives | 巴斯夫欧洲公司 | 2021-03-30 | — | — | CN | disclosed |
| WO-2020038821-A1 | SUBSTITUTED GLUTARIMIDE DERIVATIVES | BASF SE (DE) | 2020-02-27 | — | — | WO | disclosed |
| EP-3613736-A1 | SUBSTITUTED GLUTARIMIDE DERIVATIVES | BASF SE (DE) | 2020-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309649-A1 | SUBSTITUTED GLUTARIMIDE DERIVATIVES | GLRX3, GCDH, GCLC | TSHR 4844/4885CYP3A4 1578/4885TDP1 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.