SCHEMBL21751665

SCHEMBL21751665

COC(=O)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CC[C@@](C)(OC)C3)CC2)cc1Br

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 9/20 0.54
BCL2 P10415 14/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23165288 1.00 BCL2L1 (0.54) BCL2L1BCL2
SCHEMBL23165730 0.93 BCL2L1 (0.59) BCL2L1BCL2
SCHEMBL1958246 0.92 BCL2L1 (0.65) BCL2L1BCL2
SCHEMBL1957988 0.87 BCL2L1 (0.56) BCL2L1BCL2
SCHEMBL21751579 0.85 BCL2L1 (0.47) BCL2L1BCL2
SCHEMBL23165400 0.85 BCL2L1 (0.46) BCL2L1BCL2
SCHEMBL31759001 0.85 BCL2L1 (0.47) BCL2L1BCL2
SCHEMBL31759015 0.84 BCL2L1 (0.48) BCL2L1BCL2
SCHEMBL31759058 0.84 BCL2L1 (0.47) BCL2L1BCL2
SCHEMBL21751620 0.83 BCL2 (0.48) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4110298-A1 HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR Guangzhou Lupeng Pharmaceutical Company Ltd. (CN) 2023-01-04 EP disclosed
WO-2020041406-A1 BCL-2 INHIBITORS NEWAVE PHARMACEUTICAL INC. (US) 2020-02-27 WO disclosed