Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | FGR | P09769 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | TIE1 | P35590 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23761659 | 0.91 | NTRK1 (0.49) | NTRK1 | |
| SCHEMBL30921642 | 0.91 | NTRK1 (0.49) | NTRK1 | |
| SCHEMBL21752908 | 0.90 | NTRK1 (0.38) | NTRK1 | |
| SCHEMBL28594320 | 0.88 | NTRK1 (0.51) | NTRK1 | |
| SCHEMBL15428796 | 0.87 | NTRK1 (0.59) | NTRK1JAK2INSRLYNRET | |
| SCHEMBL21752815 | 0.86 | NTRK1 (0.54) | NTRK1 | |
| SCHEMBL21752834 | 0.86 | NTRK1 (0.45) | NTRK1JAK2INSRLYNRET | |
| SCHEMBL21752904 | 0.85 | NTRK1 (0.50) | NTRK1JAK2INSRLYNRET | |
| SCHEMBL21752957 | 0.84 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL21752809 | 0.84 | NTRK1 (0.43) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BenevolentAI Bio Limited (GB) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |