Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 5/20 | 0.32 |
| ▸ | SAT1 | P21673 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100023 | 1.00 | TSHR (0.43) | TSHRCYP2C19MEN1GLAKMT2A | |
| SCHEMBL20629301 | 1.00 | TSHR (0.43) | TSHRCYP2C19MEN1GLAKMT2A | |
| SCHEMBL27286241 | 0.92 | CYP2C19 (0.45) | TSHRCYP2C19MEN1GLAKMT2A | |
| SCHEMBL5932513 | 0.89 | TSHR (0.46) | TSHRCYP2C19MEN1GLAKMT2A | |
| SCHEMBL7031486 | 0.85 | TSHR (0.52) | TSHRCYP2C19MEN1GLAKMT2A | |
| SCHEMBL7109086 | 0.85 | TSHR (0.52) | TSHRCYP2C19MEN1GLAKMT2A | |
| SCHEMBL8125049 | 0.84 | TSHR (0.42) | TSHR | |
| SCHEMBL18388567 | 0.84 | TSHR (0.42) | TSHR | |
| SCHEMBL17919014 | 0.84 | TSHR (0.42) | TSHR | |
| SCHEMBL13339807 | 0.83 | TSHR (0.50) | TSHRCYP2C19MEN1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10570134-B2 | Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid | Merck & Cie (CH) | 2020-02-25 | — | — | US | disclosed |