Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.38 |
| ▸ | ERN1 | O75460 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30078023 | 0.90 | SYK (0.40) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL15065522 | 0.90 | SYK (0.40) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL21755806 | 0.88 | SYK (0.34) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL30078095 | 0.87 | KDM4E (0.42) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL15066126 | 0.87 | KDM4E (0.42) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL15065402 | 0.86 | PARP1 (0.39) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL21755827 | 0.86 | ERN1 (0.33) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL21755853 | 0.85 | SYK (0.33) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL16549759 | 0.85 | ERN1 (0.33) | SYKERN1NPC1RAB9AALDH1A1 | |
| SCHEMBL21755839 | 0.84 | ERN1 (0.32) | ERN1NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797597-B1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS INC (US) | 2020-02-26 | — | — | EP | disclosed |