Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175590 | 1.00 | MAPT (0.42) | MAPTHTTFGFR4PIN1MEN1 | |
| SCHEMBL2189170 | 0.90 | MAPT (0.43) | MAPTHTTFGFR4PIN1MEN1 | |
| SCHEMBL2174279 | 0.90 | MAPT (0.43) | MAPTHTTFGFR4PIN1MEN1 | |
| SCHEMBL2173790 | 0.86 | GSK3B (0.36) | MAPTPIN1MEN1KMT2ACYP1A2 | |
| SCHEMBL2173784 | 0.86 | GSK3B (0.36) | MAPTPIN1MEN1KMT2ACYP1A2 | |
| SCHEMBL13570614 | 0.79 | MAPT (0.46) | MAPTHTTFGFR4PIN1MEN1 | |
| SCHEMBL13570615 | 0.79 | MAPT (0.46) | MAPTHTTFGFR4PIN1MEN1 | |
| SCHEMBL16087100 | 0.78 | MAPT (0.43) | MAPTHTTFGFR4PIN1MEN1 | |
| Hydrochloric Acid SCHEMBL2176085 | 0.77 | MAPT (0.45) | MAPTHTTFGFR4PIN1MEN1 | |
| SCHEMBL17093395 | 0.76 | GSK3B (0.37) | MAPTHTTPIN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011082270-A2 | SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS | ARQULE. INC. (US) | 2011-07-07 | — | — | WO | disclosed |