Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.61 |
| ▸ | JAK1 | P23458 | 19/20 | 0.61 |
| ▸ | TYK2 | P29597 | 18/20 | 0.61 |
| ▸ | JAK3 | P52333 | 8/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23424233 | 0.91 | TYK2 (0.74) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21756992 | 0.90 | TYK2 (0.74) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757099 | 0.90 | JAK2 (0.74) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757098 | 0.87 | JAK2 (0.56) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL23424210 | 0.84 | JAK1 (0.56) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23424211 | 0.77 | JAK1 (0.55) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL23584416 | 0.77 | TYK2 (0.65) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL24742874 | 0.76 | TYK2 (0.54) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21756994 | 0.76 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 | |
| SCHEMBL21757057 | 0.75 | JAK2 (1.00) | JAK2JAK1TYK2JAK3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020038457-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINE COMPOUND AS JAK INHIBITOR AND APPLICATION THEREOF | 珠海联邦制药股份有限公司 | 2020-02-27 | — | — | WO | disclosed |