Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.72 |
| ▸ | SHBG | P04278 | 3/20 | 0.72 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.72 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.72 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | THPO | P40225 | 1/20 | 0.72 |
| ▸ | MTOR | P42345 | 1/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL137293 | 1.00 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL8668298 | 0.91 | SMN1; SMN2 (0.80) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL8668291 | 0.91 | SMN1; SMN2 (0.80) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL13449676 | 0.90 | SMN1; SMN2 (0.70) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL11125553 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL11125549 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL11125542 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL4110734 | 0.84 | CYP3A4 (0.70) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL13752943 | 0.84 | CYP3A4 (0.70) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 | |
| SCHEMBL4110739 | 0.84 | CYP3A4 (0.70) | SMN1; SMN2CYP3A4HIF1ALMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4149497-A1 | NOVEL ANUCLEATED CELLS AS A SOURCE FOR TREATMENT OF PLATELET RICH PLASMA DEPENDENT DISORDERS | Platelet Biogenesis, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |
| CN-109310727-B | Conditionally active heterodimeric polypeptides and methods of use thereof | 加利福尼亚大学董事会 | 2022-09-27 | — | — | CN | disclosed |
| US-7972782-B2 | Steroid-activated nuclear receptors and uses therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2011-07-05 | — | — | US | disclosed |
| EP-2036925-A1 | Novel steroid-activated nuclear receptors and uses therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-1235861-B1 | TRANSGENIC MOUSE EXPRESSING STEROID-ACTIVATED NUCLEAR RECEPTOR | SALK INST FOR BIOLOGICAL STUDI (US) | 2008-10-22 | — | — | EP | disclosed |
| US-7413853-B2 | Modulation of metabolism of steroids and xenobiotics | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1051479-B1 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | SALK INST FOR BIOLOGICAL STUDI (US) | 2008-07-16 | — | — | EP | disclosed |
| US-7214482-B2 | Steroid-activated nuclear receptors and uses therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2007-05-08 | — | — | US | disclosed |
| US-20070026445-A1 | Novel steroid-activated nuclear receptors and uses therefor | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2007-02-01 | — | — | US | disclosed |
| US-6984773-B1 | Transgenic mice expressing a human SXR receptor polypeptide | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2006-01-10 | — | — | US | disclosed |
| US-20030064430-A1 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-04-03 | — | — | US | disclosed |
| US-20030044888-A1 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | HOWARD HUGHES MEDICAL INSTITUTE | 2003-03-06 | — | — | US | disclosed |
| WO-2003005812-A2 | MODULATION OF METABOLISM OF STEROIDS AND XENOBIOTICS | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2003-01-23 | — | — | WO | disclosed |
| EP-1051479-A4 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | SALK INST FOR BIOLOGICAL STUDI (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1235861-A2 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2002-09-04 | — | — | EP | disclosed |
| US-6274118-B1 | INJECTING PATIENT HAVING ENDOCRINE CANCER IN NON-PROSTATIC TISSUE WITH BIOLOGICAL BINDING UNITS WHICH BIND TO PROSTATE SPECIFIC ANTIGEN PRODUCED BY NON-PROSTATIC TISSUE | NORDION INTERNATIONAL INC. (CA) | 2001-08-14 | — | — | US | disclosed |
| WO-2001042290-A2 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2001-06-14 | — | — | WO | disclosed |
| EP-1051479-A1 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999035246-A9 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | SALK INST FOR BIOLOGICAL STUDI (US) | 1999-09-30 | — | — | WO | disclosed |
| WO-1999035246-A1 | NOVEL STEROID-ACTIVATED NUCLEAR RECEPTORS AND USES THEREFOR | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1999-07-15 | — | — | WO | disclosed |