Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980849 | 0.83 | PDE10A (0.41) | PDE10AARPOLBTP53 | |
| SCHEMBL9981385 | 0.78 | PDE10A (0.46) | PDE10AMAPT | |
| SCHEMBL9982363 | 0.77 | PDE10A (0.46) | PDE10A | |
| SCHEMBL9980990 | 0.77 | PDE10A (0.44) | PDE10APOLBTP53 | |
| SCHEMBL9981245 | 0.76 | PDE10A (0.43) | PDE10APOLBTP53ALDH1A1 | |
| SCHEMBL1701334 | 0.76 | PDE10A (0.47) | PDE10AMAPT | |
| SCHEMBL9980992 | 0.75 | PDE10A (0.41) | PDE10AMAPTPOLBALDH1A1 | |
| SCHEMBL15946514 | 0.74 | PDE10A (0.46) | PDE10A | |
| SCHEMBL9981045 | 0.74 | PDE10A (0.44) | PDE10A | |
| SCHEMBL1703500 | 0.73 | PDE10A (0.41) | PDE10AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-B1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICALS CO (JP) | 2020-02-26 | — | — | EP | disclosed |