Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.69 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.69 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22511578 | 0.89 | CRBN (0.63) | CRBNDDB1IKZF3 | |
| SCHEMBL23915128 | 0.89 | CRBN (0.63) | CRBNDDB1GRM2IKZF3 | |
| SCHEMBL31553873 | 0.87 | CRBN (0.61) | CRBNDDB1IKZF3 | |
| SCHEMBL25034762 | 0.87 | CRBN (0.61) | CRBNDDB1IKZF3 | |
| SCHEMBL30274040 | 0.87 | CRBN (0.61) | CRBNDDB1IKZF3 | |
| SCHEMBL25036127 | 0.86 | DDB1 (0.60) | CRBNDDB1IKZF3 | |
| SCHEMBL30273533 | 0.86 | DDB1 (0.60) | CRBNDDB1IKZF3 | |
| SCHEMBL23945499 | 0.85 | CRBN (0.72) | CRBNDDB1IKZF3 | |
| SCHEMBL20845661 | 0.85 | CRBN (0.72) | CRBNDDB1IKZF3 | |
| SCHEMBL24029813 | 0.85 | CRBN (0.72) | CRBNDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024121259-A1 | TARGETED PROTEIN DEGRADATION USING PRODRUGS OF BIFUNCTIONAL COMPOUNDS THAT BIND UBIQUITIN LIGASE AND TARGET MCL-1 PROTEIN | CAPTOR THERAPEUTICS S.A. (PL) | 2024-06-13 | — | — | WO | disclosed |
| CN-116867758-A | IRAK degradation agents and uses thereof | 凯麦拉医疗公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-115776887-A | MDM2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2023-03-10 | — | — | CN | disclosed |
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2020038415-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2020-02-27 | — | — | WO | disclosed |