Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.61 |
| ▸ | CSF1R | P07333 | 11/20 | 0.61 |
| ▸ | MET | P08581 | 4/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174355 | 0.94 | PDGFRB (0.61) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2173849 | 0.91 | PDGFRB (0.66) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2175412 | 0.84 | PDGFRB (0.65) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2175359 | 0.80 | PDGFRB (0.59) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2176053 | 0.80 | PDGFRB (0.84) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2173846 | 0.78 | PDGFRB (0.94) | KDRPDGFRBCSF1RMETPDGFRA | |
| Sulfuric Acid SCHEMBL2174407 | 0.77 | PDGFRB (0.94) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2176080 | 0.76 | PDGFRB (1.00) | KDRPDGFRBCSF1RMETPDGFRA | |
| SCHEMBL2174350 | 0.74 | PDGFRB (0.84) | KDRPDGFRBCSF1RMETPDGFRA | |
| Fumaric Acid SCHEMBL2175416 | 0.74 | PDGFRB (0.91) | KDRPDGFRBCSF1RMETPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | disclosed |
| US-20090076074-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076074-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, CCNA1 | KDR 2277/4885PDGFRB 2155/4885CSF1R 818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.