Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.78 |
| ▸ | GLA | P06280 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | MAOB | P27338 | 7/20 | 0.71 |
| ▸ | GAPDH | P04406 | 5/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.58 |
| ▸ | CASP7 | P55210 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14880118 | 0.88 | NPC1 (1.00) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL16520513 | 0.86 | NPC1 (0.79) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL31566290 | 0.85 | NPC1 (0.81) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL3842740 | 0.85 | MAOB (0.81) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL15286102 | 0.85 | NPC1 (0.85) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL20288536 | 0.81 | NPC1 (0.79) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL28585595 | 0.81 | NPC1 (0.73) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL18523591 | 0.81 | NPC1 (0.77) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL18259010 | 0.81 | NPC1 (0.77) | NPC1RAB9AKDM4EGLAMEN1 | |
| SCHEMBL8115599 | 0.81 | NPC1 (0.77) | NPC1RAB9AKDM4EGLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001576-B2 | Compounds for optically active devices | MERCK PATENT GMBH (DE) | 2021-05-11 | — | — | US | disclosed |
| US-20200062739-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062739-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | PDE6C, PDE6A, PDE6D | NPC1 2727/4885RAB9A 1119/4885KDM4E 3992/4885 |
| US-11001576-B2 | Compounds for optically active devices | PDE6C, PDE6A, PDE6D | NPC1 2727/4885RAB9A 1119/4885KDM4E 3992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.