Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 12/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21763928 | 0.86 | GRK6 (0.46) | GRK6ALDH1A1KDM4EENPP1SMN1; SMN2 | |
| SCHEMBL21763940 | 0.86 | GRK6 (0.40) | GRK6ALDH1A1KDM4EENPP1 | |
| SCHEMBL14907743 | 0.83 | GRK6 (0.44) | GRK6ALDH1A1KDM4EEGFRERBB2 | |
| SCHEMBL16171102 | 0.83 | GRK6 (0.56) | GRK6ALDH1A1KDM4EEGFRERBB2 | |
| SCHEMBL21763996 | 0.82 | GRK6 (0.45) | GRK6ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL18552409 | 0.82 | GRK6 (0.55) | GRK6ALDH1A1KDM4EEGFRERBB2 | |
| SCHEMBL14907962 | 0.81 | GRK6 (0.67) | GRK6ALDH1A1KDM4EEGFRERBB2 | |
| SCHEMBL14907877 | 0.80 | GRK6 (0.61) | GRK6EGFRERBB2 | |
| SCHEMBL14907807 | 0.79 | GRK6 (0.49) | GRK6ALDH1A1KDM4E | |
| SCHEMBL14907795 | 0.77 | GRK6 (0.62) | GRK6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134390-B1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-02-26 | — | — | EP | disclosed |