SCHEMBL21766533

SCHEMBL21766533

CCn1nc(C)c(F)c1C(=O)Nc1nc2cc(C)cc3c2n1CC1(COC1)CO3

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
TSHR P16473 1/20 0.30
STING1 Q86WV6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21766532 0.91 STING1 (0.39) STING1
SCHEMBL21766535 0.90 STING1 (0.33) STING1
SCHEMBL21753599 0.85 STING1 (0.38) STING1
SCHEMBL23585705 0.83 STING1 (0.32) STING1
SCHEMBL21766391 0.83 STING1 (0.37) STING1
SCHEMBL21766501 0.83 ENPP1 (0.32) STING1
SCHEMBL21753369 0.81 STING1 (0.39) STING1
SCHEMBL21766438 0.75 STING1 (0.42) STING1
SCHEMBL21766433 0.75 STING1 (0.36) STING1
SCHEMBL23585695 0.75 STING1 (0.45) STING1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020038387-A1 HIGH ACTIVITY STING PROTEIN AGONIST 杭州阿诺生物医药科技有限公司 2020-02-27 WO disclosed