Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739306 | 0.85 | JAK3 (0.45) | JAK3JAK1JAK2BTK | |
| SCHEMBL22474759 | 0.83 | JAK3 (0.44) | JAK3JAK1JAK2BTKEGFR | |
| SCHEMBL17150817 | 0.83 | JAK3 (0.44) | JAK3JAK1JAK2BTKEGFR | |
| SCHEMBL19240547 | 0.83 | JAK3 (0.45) | JAK3JAK1JAK2BTKTYK2 | |
| SCHEMBL17915688 | 0.83 | JAK3 (0.45) | JAK3JAK1JAK2BTKTYK2 | |
| SCHEMBL18431347 | 0.83 | JAK3 (0.45) | JAK3JAK1JAK2BTKTYK2 | |
| SCHEMBL24541727 | 0.81 | JAK3 (0.45) | JAK3JAK1JAK2BTKTYK2 | |
| SCHEMBL21537267 | 0.81 | JAK3 (0.45) | JAK3JAK1JAK2BTKTYK2 | |
| SCHEMBL20937415 | 0.81 | JAK3 (0.45) | JAK3JAK1JAK2BTKTYK2 | |
| SCHEMBL16285092 | 0.81 | POLB (0.44) | JAK3JAK1JAK2BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036231-B1 | SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF | JUBILANT BIOSYS LTD (IN) | 2020-02-26 | — | — | EP | disclosed |