Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 4/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.34 |
| ▸ | MERTK | Q12866 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28591161 | 0.99 | BTK (0.50) | BTKKCNH2MAP4K1LRRK2TTK | |
| SCHEMBL30104402 | 0.97 | BTK (0.48) | BTKKCNH2MAP4K1LRRK2TTK | |
| Hydrochloric Acid SCHEMBL30104418 | 0.97 | BTK (0.48) | BTKKCNH2MAP4K1LRRK2TTK | |
| Hydrochloric Acid SCHEMBL30104456 | 0.89 | BTK (0.48) | BTKKCNH2 | |
| Hydrochloric Acid SCHEMBL28593369 | 0.86 | BTK (0.46) | BTKKCNH2 | |
| SCHEMBL21776833 | 0.84 | BTK (0.51) | BTKKCNH2 | |
| SCHEMBL21776936 | 0.83 | BTK (0.49) | BTKKCNH2 | |
| Hydrochloric Acid SCHEMBL28594006 | 0.83 | BTK (0.51) | BTKKCNH2 | |
| Hydrochloric Acid SCHEMBL30104462 | 0.83 | BTK (0.43) | BTKKCNH2JAK2TYK2 | |
| Hydrochloric Acid SCHEMBL30104450 | 0.83 | BTK (0.48) | BTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389004-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) | EMD Serono Research and Development Institute, Inc. | 2022-12-08 | — | — | US | disclosed |
| EP-3843847-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | Merck Patent GmbH (DE) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020043638-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | MERCK PATENT GMBH (DE) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020043638-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | MERCK PATENT GMBH (DE) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389004-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) | BTK, SYK, ABL1 | BTK 1/4885KCNH2 2077/4885MAP4K1 222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.