Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 5/20 | 0.41 |
| ▸ | KCNB1 | Q14721 | 6/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20545939 | 0.82 | CTSA (0.57) | CTSAPTGDR2 | |
| SCHEMBL20545938 | 0.82 | CTSA (0.57) | CTSAPTGDR2 | |
| SCHEMBL29793545 | 0.82 | PDPK1 (0.51) | LOXL2PDPK1CYP2A6CTSAKCNB1 | |
| SCHEMBL5888543 | 0.82 | PDPK1 (0.51) | LOXL2PDPK1CYP2A6CTSAKCNB1 | |
| SCHEMBL28405984 | 0.82 | PDPK1 (0.51) | LOXL2PDPK1CYP2A6CTSAKCNB1 | |
| SCHEMBL13801391 | 0.78 | PDPK1 (0.55) | LOXL2PDPK1CYP2A6CTSAKCNB1 | |
| SCHEMBL15805858 | 0.77 | PDPK1 (0.72) | LOXL2PDPK1CYP2A6PTGDR2CARM1 | |
| SCHEMBL30671345 | 0.77 | KCNB1 (0.51) | CTSAKCNB1KCNA5 | |
| SCHEMBL24227164 | 0.77 | PDPK1 (0.49) | LOXL2PDPK1CYP2A6CTSAKCNB1 | |
| SCHEMBL27992983 | 0.76 | PDPK1 (0.51) | LOXL2PDPK1CYP2A6CTSAKCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843724-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | National Health Research Institutes (TW) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047360-A1 | BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2020-03-05 | — | — | WO | disclosed |