Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345745 | 0.95 | ATM (0.37) | L3MBTL1ATMKDM4ELMNACFTR | |
| SCHEMBL9337391 | 0.83 | HTR2A (0.41) | PDE1CPDE1BL3MBTL1SCN9AATM | |
| SCHEMBL21780613 | 0.81 | KDM4E (0.44) | PDE1CPDE1BL3MBTL1ATMGRIN2B | |
| SCHEMBL20225794 | 0.80 | KDM1A (0.43) | PDE1CL3MBTL1SCN9AGRIN2BKDM4E | |
| SCHEMBL20226132 | 0.80 | KDM1A (0.43) | PDE1CL3MBTL1SCN9AGRIN2BKDM4E | |
| SCHEMBL20013058 | 0.78 | HTR2A (0.42) | L3MBTL1ATMKDM4ELMNACFTR | |
| SCHEMBL13749069 | 0.78 | HTR2A (0.42) | L3MBTL1ATMKDM4ELMNACFTR | |
| SCHEMBL21767418 | 0.76 | SLC6A2 (0.30) | — | |
| SCHEMBL31071982 | 0.76 | SLC6A2 (0.30) | — | |
| SCHEMBL15741269 | 0.76 | HTR2C (0.40) | LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617206-A1 | INTEGRIN INHIBITORS | Morphic Therapeutic, Inc. (US) | 2020-03-04 | — | — | EP | disclosed |