Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 7/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780738 | 0.88 | KDM1A (0.54) | HRH3ESR1KDM1A | |
| SCHEMBL17845116 | 0.86 | ESR1 (0.49) | ESR1LTA4HKDM4ESIGMAR1TMEM97 | |
| SCHEMBL17845086 | 0.86 | ESR1 (0.49) | ESR1LTA4HKDM4ESIGMAR1TMEM97 | |
| SCHEMBL17845197 | 0.86 | ESR1 (0.59) | ESR1LTA4H | |
| SCHEMBL17845198 | 0.86 | ESR1 (0.59) | ESR1LTA4H | |
| SCHEMBL21780869 | 0.86 | TMEM97 (0.63) | ESR1LTA4HKDM1ASIGMAR1TMEM97 | |
| SCHEMBL23474881 | 0.85 | KDM4E (0.60) | HRH3ESR1LTA4HKDM4E | |
| SCHEMBL23474993 | 0.85 | MEN1 (0.52) | ESR1LTA4HKDM4ESIGMAR1TMEM97 | |
| SCHEMBL23474962 | 0.85 | KDM4E (0.60) | HRH3ESR1LTA4HKDM4E | |
| SCHEMBL23474994 | 0.85 | KDM4E (0.60) | HRH3ESR1LTA4HKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |