(R,R)-Mefloquine

(R,R)-Mefloquine

SCHEMBL21781

O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCCN1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 8/20 1.00
CYP2D6 P10635 6/20 1.00
ADORA2A P29274 5/20 1.00
ADORA1 P30542 5/20 1.00
CYP3A4 P08684 4/20 1.00
CYP1A2 P05177 4/20 1.00
CYP2C19 P33261 3/20 1.00
ADORA3 P0DMS8 2/20 1.00
ADORA2B P29275 1/20 1.00
ABCG2 Q9UNQ0 1/20 1.00
KDM4E B2RXH2 1/20 1.00
NR1I2 O75469 1/20 1.00
LMNA P02545 1/20 1.00
TP53 P04637 1/20 1.00
HTR1A P08908 1/20 1.00
TSHR P16473 1/20 1.00
CNR1 P21554 1/20 1.00
GLRA1 P23415 1/20 1.00
SLC6A2 P23975 1/20 1.00
HTR2A P28223 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(S,R)-Mefloquine SCHEMBL32385911 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
(S,R)-Mefloquine SCHEMBL16702641 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
Mefloquine SCHEMBL8575605 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
Mefloquine SCHEMBL17087807 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
(S,S)-Mefloquine SCHEMBL7278974 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
Mefloquine SCHEMBL3625982 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
Mefloquine SCHEMBL21782 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
Mefloquine SCHEMBL7130867 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
(S,R)-Mefloquine SCHEMBL21780 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4
Mefloquine SCHEMBL29433990 1.00 KCNH2 (1.00) KCNH2CYP2D6ADORA2AADORA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17723 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094963-A Cardioprotective lipids and methods of use 2026-05-26 CN claimed
EP-4741492-A2 NECROSIS INHIBITOR Linkgevity Limited (GB) 2026-05-13 EP claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP claimed
US-20260027215-A1 COMPOSITIONS FOR TRANSPORT OF THERAPEUTIC CARGOS USING BINDERS TARGETING CA-IV RECEPTIVE BIO INC (US) 2026-01-29 US claimed
EP-4680608-A1 2,6-DIHYDRO-7H-PYRAZOLO[3,4-C]PYRIDIN-7-ONE DERIVATIVES AS ANTI-MALARIAL AGENTS MMV Medicines for Malaria Venture (CH) 2026-01-21 EP claimed
EP-4680248-A1 PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM Topelia Aust Limited (ACN 652 771 670) (AU) 2026-01-21 EP claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
US-12509439-B2 Anti-malarial agents UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2025-12-30 US claimed
US-20250388603-A1 ANTIMALARIAL COMPOUNDS SCRIPPS RESEARCH INST (US) 2025-12-25 US claimed
WO-1989008658-A1 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1989-09-21 WO claimed
EP-0332657-A1 ANTIMALARIAL COMPOSITIONS AND METHODS The Department of the Army Engineer Research and Development Center, Corps of Engineers (US) 1989-09-20 EP claimed
EP-0332657-A4 ANTIMALARIAL COMPOSITIONS AND METHODS. US SEC THE ARMY INTELLECTUAL P (US) 1989-08-22 EP claimed
US-4826689-A PRECIPITATION FROM SOLUTION IN ORGANIC SOLVENT UNIVERSITY OF ROCHESTER (US) 1989-05-02 US claimed
WO-1988003802-A1 ANTIMALARIAL COMPOSITIONS AND METHODS UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE (US) 1988-06-02 WO claimed
EP-0092185-B1 MEFLOQUINE-HYDROCHLORIDE AND PROCESS FOR ITS HIGH PURITY PREPARATION F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1988-04-20 EP claimed
EP-0169618-A2 Method for making uniformly sized particles from water-insoluble organic compounds STERILIZATION TECHNICAL SERVICES, Inc. (US) 1986-01-29 EP claimed
EP-0154491-A2 Quinate salts of the antimalarial compound mefloquine SMITHKLINE BEECHAM CORPORATION (US) 1985-09-11 EP claimed
EP-0001796-B1 ANTI-MALARIA DRUG HOECHST AKTIENGESELLSCHAFT (DE) 1981-06-10 EP claimed
EP-0001796-A1 Anti-malaria drug HOECHST AKTIENGESELLSCHAFT (DE) 1979-05-16 EP claimed