Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | CLK1 | P49759 | 3/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177127 | 0.92 | MKNK1 (0.55) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL2179063 | 0.92 | DYRK1A (0.53) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL2181493 | 0.91 | MTOR (0.47) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL2178288 | 0.91 | MTOR (0.48) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL2179106 | 0.90 | DYRK1A (0.52) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL10272914 | 0.90 | DYRK1A (0.50) | DYRK1ACLK4CLK1MKNK1DYRK1B | |
| Hydrochloric Acid SCHEMBL2177661 | 0.89 | DYRK1A (0.49) | DYRK1ACLK4CLK1MKNK1DYRK1B | |
| SCHEMBL2177110 | 0.88 | MKNK1 (0.47) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL2177503 | 0.87 | PIK3CA (0.47) | DYRK1ACLK4CLK1MTORSMG1 | |
| SCHEMBL6126115 | 0.87 | MKNK1 (0.53) | DYRK1ACLK4CLK1MTORSMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | claimed |
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173808-B2 | Substituted naphthalenyl-pyrimidine compounds | ARQULE, INC. (US) | 2012-05-08 | — | — | US | disclosed |
| WO-2011082268-A2 | SUBSTITUTED NAPHTHALENYL-PYRIMIDINE COMPOUNDS | ARQULE INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | DYRK1A 2574/4885CLK4 3301/4885CLK1 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.