Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783190 | 1.00 | BCHE (0.55) | BCHEACHESCN9APSEN1PSEN2 | |
| SCHEMBL21783279 | 0.88 | BCHE (0.57) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL404038 | 0.84 | BCHE (0.47) | BCHEACHESCN9APSEN1PSEN2 | |
| SCHEMBL20995912 | 0.79 | PSEN1 (0.53) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL21783194 | 0.77 | BCHE (0.52) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL32691141 | 0.77 | BCHE (0.48) | BCHEACHESCN9ATSHRPDE4D | |
| SCHEMBL24008144 | 0.75 | PSEN1 (0.48) | BCHEPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13942035 | 0.75 | SCN9A (0.50) | SCN9ATSHRPDE4DCTSLCTSB | |
| SCHEMBL11992975 | 0.75 | PSEN1 (0.48) | BCHEACHEPSEN1PSEN2APH1B | |
| SCHEMBL18942566 | 0.75 | PSEN1 (0.48) | BCHEACHEPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020046132-A1 | PHARMACOLOGICAL CHAPERONES FOR ENZYME TREATMENT THERAPY | LEIDEN UNIVERSITY (NL) | 2020-03-05 | — | — | WO | disclosed |