Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.84 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.61 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176614 | 0.91 | PIM1 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL2176300 | 0.82 | PIM1 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL14762139 | 0.81 | PIM2 (0.91) | PIM1PIM2PIM3 | |
| SCHEMBL2179124 | 0.81 | PIM1 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL12494539 | 0.78 | PIM1 (0.91) | PIM1PIM2PIM3 | |
| SCHEMBL14762210 | 0.76 | PIM2 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL12496028 | 0.76 | PIM1 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL12497724 | 0.75 | PIM1 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL2179053 | 0.75 | PIM3 (1.00) | PIM1PIM2PIM3 | |
| SCHEMBL15602920 | 0.74 | PIM1 (0.83) | PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519526-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080510-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2011-07-07 | — | — | WO | disclosed |