Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 10/20 | 0.51 |
| ▸ | BCOR | Q6W2J9 | 10/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20773220 | 0.75 | BCL6 (0.51) | BCL6BCORAURKAAURKBMAPT | |
| SCHEMBL30832785 | 0.75 | BCL6 (0.51) | BCL6BCORAURKAAURKBMAPT | |
| SCHEMBL24270834 | 0.72 | GAA (0.50) | BCL6MAPTGAAALDH1A1HPGD | |
| SCHEMBL29492714 | 0.72 | GAA (0.50) | BCL6MAPTGAAALDH1A1HPGD | |
| SCHEMBL29492772 | 0.70 | MAPT (0.52) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL24270569 | 0.70 | MAPT (0.52) | MAPTGAAALDH1A1KDM4EMEN1 | |
| SCHEMBL23535544 | 0.68 | ROCK1 (0.49) | BCL6BCORMAPTGAAALDH1A1 | |
| SCHEMBL20772501 | 0.68 | BCL6 (0.71) | BCL6BCORMAPTGAAALDH1A1 | |
| SCHEMBL12941910 | 0.68 | TYRO3 (0.50) | AURKAAURKBMAPTALDH1A1HPGD | |
| SCHEMBL24270517 | 0.68 | MTOR (0.40) | MAPTGAAHPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210346353-A1 | CD73 INHIBITORS | ARCUS BIOSCIENCES, INC. | 2021-11-11 | — | — | US | disclosed |
| WO-2020046813-A1 | CD73 INHIBITORS | ARCUS BIOSCIENCES, INC. (US) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210346353-A1 | CD73 INHIBITORS | ENTPD5, ENTPD1, NT5E | BCL6 1416/4885BCOR 3223/4885AURKA 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.