Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 3/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.31 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148879 | 0.87 | AR (0.41) | ARKDM4EALDH1A1PDE5AALPL | |
| SCHEMBL20139673 | 0.87 | AR (0.34) | ARKDM4EALDH1A1METAP2PDE5A | |
| SCHEMBL21564214 | 0.80 | AR (0.37) | ARKDM4EALDH1A1METAP2PDE5A | |
| SCHEMBL21787186 | 0.78 | AR (0.38) | ARKDM4EALDH1A1PDE5AALPL | |
| SCHEMBL21564207 | 0.73 | AR (0.39) | ARKDM4EALDH1A1PDE5AGUCY1A1 | |
| SCHEMBL20148902 | 0.73 | HIF1A (0.43) | ARKDM4EALDH1A1PDE5AALPL | |
| SCHEMBL20148877 | 0.73 | AR (0.39) | ARKDM4EALDH1A1PDE5AGUCY1A1 | |
| SCHEMBL20148918 | 0.73 | AR (0.40) | ARKDM4EALDH1A1PDE5AGUCY1A1 | |
| SCHEMBL20140398 | 0.73 | CYP19A1 (0.34) | ARKDM4EALDH1A1ADRB2NPC1 | |
| SCHEMBL20140279 | 0.72 | KMT2A (0.39) | KDM4EALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017515-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2022-01-20 | — | — | US | disclosed |
| US-11180493-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200071318-A1 | SGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071318-A1 | SGC STIMULATORS | GUCY1A2, GMPS, PDE2A | AR 4566/4885KDM4E 3627/4885ALDH1A1 2298/4885 |
| US-20220017515-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, PDE2A | AR 4568/4885KDM4E 3552/4885ALDH1A1 2355/4885 |
| US-11180493-B2 | SGC stimulators | GUCY1A2, GMPS, PDE2A | AR 4566/4885KDM4E 3627/4885ALDH1A1 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.