Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21787375 | 0.86 | KDM4E (0.30) | KDM4EHPGDHSD17B10 | |
| SCHEMBL21787372 | 0.76 | — | — | |
| SCHEMBL21787387 | 0.73 | MAPT (0.33) | HPGD | |
| SCHEMBL21787369 | 0.70 | — | — | |
| SCHEMBL21787370 | 0.69 | KDM4E (0.31) | KDM4EHPGDHSD17B10 | |
| SCHEMBL21787384 | 0.69 | — | — | |
| SCHEMBL21787383 | 0.68 | KDM4E (0.30) | KDM4EHPGDHSD17B10 | |
| SCHEMBL21787373 | 0.68 | CSNK2A1 (0.30) | — | |
| SCHEMBL21787371 | 0.66 | — | — | |
| SCHEMBL21787376 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180493-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200071318-A1 | SGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2020-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071318-A1 | SGC STIMULATORS | GUCY1A2, GMPS, PDE2A | KDM4E 3627/4885HPGD 78/4885HSD17B10 2294/4885 |
| US-11180493-B2 | SGC stimulators | GUCY1A2, GMPS, PDE2A | KDM4E 3627/4885HPGD 78/4885HSD17B10 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.