SCHEMBL21787573

SCHEMBL21787573

COCCOc1cc2cc(Nc3nc(N4CCC(F)CC4)ncc3Cl)ccc2n(C)c1=O

nearest known ligand 0.60

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.60
▸ NCOR2 Q9Y618 8/20 0.60
▸ MELK Q14680 1/20 0.59
▸ CHRM4 P08173 1/20 0.49
▸ BCL6B Q8N143 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20284218 0.89 BCL6 (0.67) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284569 0.88 BCL6 (0.68) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284198 0.87 BCL6 (0.78) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL21787579 0.85 BCL6 (0.66) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284084 0.85 BCL6 (0.74) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23268040 0.84 BCL6 (0.64) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267516 0.84 BCL6 (0.59) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267525 0.83 BCL6 (0.58) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267493 0.82 BCL6 (0.66) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284725 0.82 BCL6 (0.79) BCL6NCOR2MELKCHRM4BCL6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11001570-B2 6-amino-quinolinone compounds and derivatives as BCL6 inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-05-11 — — US disclosed
US-20200071297-A1 NEW 6-AMINO-QUINOLINONE COMPOUNDS AND DERIVATIVES AS BCL6 INHIBITORS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2020-03-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200071297-A1 NEW 6-AMINO-QUINOLINONE COMPOUNDS AND DERIVATIVES AS BCL6 INHIBITORS BCL6, BCL6B, BCOR BCL6 1/4885NCOR2 101/4885MELK 393/4885
US-11001570-B2 6-amino-quinolinone compounds and derivatives as BCL6 inhibitors BCL6, BCL6B, BCOR BCL6 1/4885NCOR2 90/4885MELK 366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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