Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18022528 | 1.00 | MEN1 (0.51) | MEN1KMT2AKDM1AKDM1BHTR2C | |
| SCHEMBL21547405 | 0.83 | MEN1 (0.44) | MEN1KMT2AHTR2CHTR2BSLC6A2 | |
| SCHEMBL17113820 | 0.81 | HTR2C (0.43) | KDM1AHTR2CHTR2BMAOAMAOB | |
| SCHEMBL17086752 | 0.81 | HTR2C (0.43) | KDM1AHTR2CHTR2BMAOAMAOB | |
| SCHEMBL17086753 | 0.81 | HTR2C (0.43) | KDM1AHTR2CHTR2BMAOAMAOB | |
| SCHEMBL14908010 | 0.81 | KDM1A (0.59) | MEN1KMT2AKDM1AKDM1BHTR2C | |
| SCHEMBL16110654 | 0.81 | KDM1A (0.59) | MEN1KMT2AKDM1AKDM1BHTR2C | |
| SCHEMBL17460933 | 0.79 | BRD4 (0.48) | HTR2CHTR2BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19223236 | 0.79 | MEN1 (0.49) | MEN1KMT2AKDM1AKDM1BHTR2C | |
| SCHEMBL17864278 | 0.79 | HTR2A (0.44) | MEN1KMT2AHTR2CHTR2BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020046966-A1 | TREATMENT OF ADENOCARCINOMAS WITH MAPK PATHWAY INHIBITORS | KURA ONCOLOGY, INC. (US) | 2020-03-05 | — | — | WO | disclosed |