Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.85 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18024672 | 0.92 | MAPK1 (1.00) | MAPK1HPGDSDRD2DRD4DRD3 | |
| SCHEMBL16630950 | 0.91 | MAPK1 (0.83) | MAPK1HPGDS | |
| SCHEMBL19775553 | 0.91 | MAPK1 (0.79) | MAPK1HPGDSITKDRD2HTR2A | |
| SCHEMBL16631073 | 0.90 | MAPK1 (1.00) | MAPK1ITKDRD2HTR2AHTR2C | |
| SCHEMBL16631176 | 0.90 | MAPK1 (0.86) | MAPK1 | |
| SCHEMBL18024369 | 0.88 | MAPK1 (1.00) | MAPK1KCNH2 | |
| SCHEMBL16630989 | 0.86 | MAPK1 (0.82) | MAPK1 | |
| SCHEMBL16631018 | 0.79 | MAPK1 (1.00) | MAPK1 | |
| SCHEMBL18024487 | 0.77 | MAPK1 (0.71) | MAPK1 | |
| SCHEMBL21107733 | 0.75 | MAPK1 (0.71) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020046966-A1 | TREATMENT OF ADENOCARCINOMAS WITH MAPK PATHWAY INHIBITORS | KURA ONCOLOGY, INC. (US) | 2020-03-05 | — | — | WO | disclosed |