Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.63 |
| ▸ | BRD2 | P25440 | 3/20 | 0.63 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.63 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | BRD1 | O95696 | 1/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CCL2 | P13500 | 1/20 | 0.42 |
| ▸ | TAF1 | P21675 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21788068 | 0.91 | BRD4 (0.76) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787876 | 0.91 | BRD4 (0.76) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787959 | 0.81 | BRD4 (0.78) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787806 | 0.81 | BRD4 (0.78) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787819 | 0.79 | BRD4 (0.84) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787870 | 0.77 | BRD4 (1.00) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21788066 | 0.77 | BRD4 (1.00) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787725 | 0.77 | BRD4 (1.00) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21787815 | 0.76 | BRD4 (0.83) | BRD4BRD2BRD3BRDT | |
| SCHEMBL21788064 | 0.76 | BRD4 (0.78) | BRD4BRD2BRD3BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043821-A1 | FURAN DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2020-03-05 | — | — | WO | disclosed |