Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994522 | 0.91 | USP2 (0.47) | EPHX2USP2SMN1; SMN2HDAC2HDAC1 | |
| SCHEMBL3295187 | 0.88 | EPHX2 (0.36) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL13737672 | 0.88 | EPHX2 (0.36) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL27947023 | 0.88 | EPHX2 (0.36) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL24340106 | 0.84 | USP2 (0.44) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL31566859 | 0.84 | USP2 (0.44) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL31566671 | 0.84 | USP2 (0.44) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL17682649 | 0.84 | KDM5A (0.47) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL31566655 | 0.83 | EPHX2 (0.41) | EPHX2USP2SMN1; SMN2HDAC2PIK3R1 | |
| SCHEMBL16887631 | 0.81 | CYP4F2 (0.40) | EPHX2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |