Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777929 | 0.88 | EPHX2 (0.43) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL21789124 | 0.88 | EPHX2 (0.47) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL21777896 | 0.85 | MAPT (0.46) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL21777316 | 0.84 | EPHX2 (0.45) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL16838991 | 0.81 | SSTR3 (0.44) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL21777482 | 0.80 | HPGD (0.45) | HPGDSMN1; SMN2 | |
| SCHEMBL29116612 | 0.80 | PPARG (0.41) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL16839832 | 0.73 | PPARG (0.46) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL16839837 | 0.73 | KCNQ2 (0.47) | PPARGEPHX2KCNQ2KCNQ3KDM4E | |
| SCHEMBL16839878 | 0.73 | KCNQ2 (0.44) | PPARGEPHX2KCNQ2KCNQ3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |