Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17664642 | 0.87 | TYRO3 (0.47) | BTKAXLTYRO3MERTK | |
| SCHEMBL21791548 | 0.86 | BTK (0.42) | BTKCREBBPKCNH2AURKAAURKB | |
| Hydrochloric Acid SCHEMBL17646063 | 0.86 | TYRO3 (0.47) | BTKAXLTYRO3MERTK | |
| Hydrochloric Acid SCHEMBL28593369 | 0.84 | BTK (0.46) | BTKCREBBPKCNH2 | |
| Hydrochloric Acid SCHEMBL30104456 | 0.83 | BTK (0.48) | BTKCREBBPKCNH2AURKAAURKB | |
| SCHEMBL27457324 | 0.80 | BTK (0.53) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL17646049 | 0.80 | AURKA (0.46) | BTKAURKAAURKBINCENPTPX2 | |
| SCHEMBL21791517 | 0.79 | BTK (0.45) | BTKAURKA | |
| SCHEMBL21791384 | 0.79 | BRD4 (0.39) | BTKKCNH2AURKA | |
| SCHEMBL17645808 | 0.78 | BTK (0.48) | BTKKCNH2ROCK2AXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043638-A1 | FUSED IMIDAZOPYRIDINES AS REVERSIBLE INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) | MERCK PATENT GMBH (DE) | 2020-03-05 | — | — | WO | disclosed |