Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.57 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.57 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795387 | 0.86 | TLR9 (0.78) | TLR9TLR7TLR8USP30PARP1 | |
| SCHEMBL21795383 | 0.86 | TLR9 (0.78) | TLR9TLR7TLR8USP30PARP1 | |
| SCHEMBL26439553 | 0.85 | TLR9 (0.73) | TLR9TLR7TLR8USP30TSHR | |
| SCHEMBL23943081 | 0.84 | TLR9 (0.62) | TLR9TLR7TLR8USP30PARP1 | |
| SCHEMBL21776661 | 0.84 | TLR9 (0.62) | TLR9TLR7TLR8USP30PARP1 | |
| SCHEMBL21776695 | 0.76 | TLR8 (0.60) | TLR9TLR7TLR8USP30TSHR | |
| SCHEMBL29722630 | 0.73 | TLR8 (0.61) | TLR9TLR7TLR8USP30PARP1 | |
| SCHEMBL19000110 | 0.73 | TLR8 (0.61) | TLR9TLR7TLR8USP30PARP1 | |
| SCHEMBL29722264 | 0.73 | TLR9 (0.66) | TLR9TLR7TLR8USP30TSHR | |
| SCHEMBL19000107 | 0.73 | TLR9 (0.66) | TLR9TLR7TLR8USP30TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844159-B1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN LA ROCHE (CH) | 2023-05-03 | — | — | EP | disclosed |
| WO-2020043271-A1 | NOVEL PYRROLIDINYL AMIDE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-05 | — | — | WO | disclosed |