Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 6/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380418 | 0.80 | TDP1 (0.48) | TDP1F2PRSS1CYP2D6EPHX1 | |
| SCHEMBL4765060 | 0.80 | TDP1 (0.48) | TDP1F2PRSS1CYP2D6EPHX1 | |
| SCHEMBL2955171 | 0.80 | TDP1 (0.48) | TDP1F2PRSS1CYP2D6EPHX1 | |
| SCHEMBL12057456 | 0.78 | TDP1 (0.54) | TDP1OPRK1OPRD1CYP2D6SIRT2 | |
| SCHEMBL29771340 | 0.77 | TDP1 (0.39) | TDP1OPRK1OPRD1SIRT2SIRT1 | |
| SCHEMBL3187239 | 0.76 | KMT2A (0.50) | TDP1EPHX1KMT2A | |
| SCHEMBL17980993 | 0.76 | KMT2A (0.50) | TDP1EPHX1KMT2A | |
| SCHEMBL3187247 | 0.76 | KMT2A (0.50) | TDP1EPHX1KMT2A | |
| SCHEMBL2683152 | 0.75 | CYP2D6 (0.58) | TDP1F2PRSS1CYP2D6EPHX1 | |
| SCHEMBL529683 | 0.75 | CYP2D6 (0.58) | TDP1F2PRSS1CYP2D6EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464268-B1 | NOVEL COMPOUNDS | CHIESI FARM SPA (IT) | 2020-03-11 | — | — | EP | disclosed |