Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 1.00 |
| ▸ | AXL | P30530 | 1/20 | 0.86 |
| ▸ | JAK1 | P23458 | 2/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14377761 | 1.00 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL14377373 | 1.00 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL29380081 | 0.93 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL14331950 | 0.93 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL18700275 | 0.90 | JAK2 (0.82) | JAK2AXLJAK1 | |
| SCHEMBL14377781 | 0.90 | JAK2 (0.82) | JAK2AXLJAK1 | |
| SCHEMBL14377472 | 0.89 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL21799094 | 0.89 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL14331838 | 0.88 | JAK2 (1.00) | JAK2AXLJAK1JAK3 | |
| SCHEMBL14332136 | 0.87 | JAK2 (1.00) | JAK2AXLJAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200079783-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2020-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200079783-A1 | AZETIDINYL PHENYL, PYRIDYL OR PYRAZINYL CARBOXAMIDE DERIVATIVES AS JAK INHIBITORS | JAK1, JAK3, JAK2 | JAK2 3/4885AXL 526/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.