Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 1.00 |
| ▸ | ERBB3 | P21860 | 1/20 | 1.00 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.77 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.76 |
| ▸ | JAK3 | P52333 | 2/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29617536 | 1.00 | EGFR (1.00) | EGFRERBB3DUS2ERBB2KDR | |
| SCHEMBL29478966 | 1.00 | EGFR (1.00) | EGFRERBB3DUS2ERBB2KDR | |
| SCHEMBL19480001 | 0.91 | EGFR (0.83) | EGFRERBB3DUS2ERBB2KDR | |
| SCHEMBL29731552 | 0.90 | EGFR (0.82) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL22847994 | 0.90 | EGFR (0.82) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL30474633 | 0.89 | EGFR (0.81) | EGFRERBB3DUS2ERBB2KDR | |
| SCHEMBL19185507 | 0.89 | EGFR (0.81) | EGFRERBB3DUS2ERBB2KDR | |
| SCHEMBL25649216 | 0.88 | EGFR (0.78) | EGFRERBB3DUS2ERBB2KDR | |
| SCHEMBL25829 | 0.88 | EGFR (0.80) | EGFRERBB3DUS2ERBB2ERBB4 | |
| SCHEMBL18862642 | 0.88 | EGFR (0.80) | EGFRERBB3DUS2ERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849538-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2021-07-21 | — | — | EP | claimed |
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | claimed |
| EP-3849538-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |