SCHEMBL21802686

SCHEMBL21802686

Cc1n[nH]cc1-c1ccc(-n2ncc3c(=O)n(CC4(O)CCN(C(=O)c5ccc(F)cc5)CC4)cnc32)cc1

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
USP7 Q93009 20/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19888832 0.88 USP7 (0.71) USP7
SCHEMBL17869577 0.87 USP7 (0.67) USP7
SCHEMBL17870459 0.87 USP7 (0.65) USP7
SCHEMBL17870314 0.86 USP7 (0.62) USP7
SCHEMBL17868924 0.85 USP7 (0.80) USP7
SCHEMBL17870174 0.85 USP7 (0.68) USP7
SCHEMBL17894884 0.85 USP7 (0.68) USP7
SCHEMBL17870463 0.85 USP7 (0.63) USP7
SCHEMBL17870407 0.85 USP7 (0.63) USP7
SCHEMBL17870081 0.85 USP7 (0.68) USP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3623372-A1 PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS Forma Therapeutics, Inc. (US) 2020-03-18 EP disclosed