Sugi Predict

Sugi Predict / Compounds / SCHEMBL21808409

SCHEMBL21808409

SCHEMBL21808409

C[C@@H]1CN(c2ccc(-c3nn(COCC[Si](C)(C)C)c4cnc(Cl)nc34)cn2)CCN1C(=O)O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 3/20 0.35
▸ FGFR2 P21802 3/20 0.35
▸ CHRM2 P08172 2/20 0.34
▸ CHRM1 P11229 2/20 0.34
▸ CHRM4 P08173 2/20 0.34
▸ DGAT1 O75907 2/20 0.34
▸ FGFR3 P22607 2/20 0.34
▸ HDAC1 Q13547 4/20 0.33
▸ GRM1 Q13255 2/20 0.33
▸ HDAC2 Q92769 2/20 0.33
▸ MAP4K4 O95819 1/20 0.33
▸ CXCR3 P49682 2/20 0.33
▸ WNT3A P56704 2/20 0.33
▸ HDAC3 O15379 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ SLC6A4 P31645 1/20 0.33
▸ SLC6A3 Q01959 1/20 0.33
▸ MAPKAPK3 Q16644 1/20 0.33
▸ HDAC8 Q9BY41 1/20 0.33
▸ ACVR1 Q04771 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21808414 1.00 FGFR1 (0.35) FGFR1FGFR2CHRM2CHRM1CHRM4
SCHEMBL21846805 0.91 MAP4K4 (0.44) FGFR1FGFR2DGAT1FGFR3HDAC1
SCHEMBL30767299 0.91 MAP4K4 (0.44) FGFR1FGFR2DGAT1FGFR3HDAC1
SCHEMBL21808616 0.88 ACVR1 (0.45) FGFR1FGFR2FGFR3ACVR1
SCHEMBL21808619 0.88 ACVR1 (0.45) FGFR1FGFR2FGFR3ACVR1
SCHEMBL21815521 0.86 FGFR2 (0.41) FGFR1FGFR2CHRM2CHRM1CHRM4
SCHEMBL21808321 0.84 ACVR1 (0.39) FGFR1FGFR2FGFR3WNT3AACVR1
SCHEMBL21808320 0.84 ACVR1 (0.39) FGFR1FGFR2FGFR3WNT3AACVR1
SCHEMBL21846697 0.81 FGFR2 (0.43) FGFR1FGFR2FGFR3HDAC1MAP4K4
SCHEMBL30767291 0.81 FGFR2 (0.43) FGFR1FGFR2FGFR3HDAC1MAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3856348-B1 PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 AND/OR FGFR MODULATORS INCYTE CORP (US) 2024-01-03 — — EP disclosed
US-20220017521-A1 PYRAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2022-01-20 — — US disclosed
US-11111247-B2 Pyrazolopyrimidine compounds and uses thereof INCYTE CORPORATION (US) 2021-09-07 — — US disclosed
EP-3856348-A1 PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS Incyte Corporation (US) 2021-08-04 — — EP disclosed
WO-2020068729-A1 PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 ABD/OR FGFR MODULATORS INCYTE CORPORATION (US) 2020-04-02 — — WO disclosed
US-20200095250-A1 PYRAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2020-03-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200095250-A1 PYRAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF ALK, FGFR1, FGFR2 FGFR1 2/4885FGFR2 3/4885CHRM2 3789/4885
US-20220017521-A1 PYRAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF ALK, FGFR1, FGFR2 FGFR1 2/4885FGFR2 3/4885CHRM2 3789/4885
US-11111247-B2 Pyrazolopyrimidine compounds and uses thereof ALK, FGFR1, FGFR2 FGFR1 2/4885FGFR2 3/4885CHRM2 3789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.