SCHEMBL21813335

SCHEMBL21813335

COC(=O)c1csc2c(C(F)(F)F)c(C)c(OC3CCN(C(=O)OC(C)(C)C)CC3)nc12

nearest known ligand 0.50

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ EED O75530 2/20 0.50
▸ RBBP4 Q09028 2/20 0.50
▸ SUZ12 Q15022 2/20 0.50
▸ EZH2 Q15910 2/20 0.50
▸ AEBP2 Q6ZN18 2/20 0.50
▸ GPR119 Q8TDV5 11/20 0.45
▸ PIK3CD O00329 4/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ TRPV1 Q8NER1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21862150 0.91 UGT8 (0.46) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL30845059 0.91 UGT8 (0.46) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21813658 0.88 EED (0.39) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21813548 0.88 EED (0.45) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL30845409 0.88 EED (0.45) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL21813545 0.88 EED (0.45) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL30845110 0.86 UGT8 (0.48) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL30844957 0.81 UGT8 (0.45) GPR119PIK3CD
SCHEMBL21813517 0.80 UGT8 (0.46) KDM4E
SCHEMBL21862149 0.79 UGT8 (0.42) EEDRBBP4SUZ12EZH2AEBP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113423711-B Thieno [3,2-B ] pyridine derivatives as UDP glycosyltransferase inhibitors and methods of use thereof 建新公司 2024-03-15 — — CN disclosed
US-20200102324-A1 UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE GENZYME CORPORATION 2020-04-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200102324-A1 UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE MAN2B1, GAA, GBA1 EED 1108/4885RBBP4 3426/4885SUZ12 3425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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