SCHEMBL21813823

SCHEMBL21813823

CNC(=O)c1csc2c(C(F)(F)F)cc(N3CC(OCCOCC4CC4)C3)nc12

nearest known ligand 0.70

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
UGT8 Q16880 20/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21813924 0.93 UGT8 (0.71) UGT8
SCHEMBL21813875 0.87 UGT8 (0.70) UGT8
SCHEMBL21813488 0.87 UGT8 (0.77) UGT8
SCHEMBL30844913 0.87 UGT8 (0.77) UGT8
SCHEMBL21813411 0.85 UGT8 (0.75) UGT8
SCHEMBL21813313 0.83 UGT8 (0.66) UGT8
SCHEMBL21813701 0.82 UGT8 (0.64) UGT8
SCHEMBL21813699 0.82 UGT8 (0.64) UGT8
SCHEMBL30845001 0.82 UGT8 (0.64) UGT8
SCHEMBL21813945 0.81 UGT8 (0.69) UGT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102324-A1 UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE GENZYME CORPORATION 2020-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200102324-A1 UDP GLYCOSYLTRANSFERASE INHIBITORS AND METHODS OF USE MAN2B1, GAA, GBA1 UGT8 74/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.