Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 9/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 7/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946813 | 1.00 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL20359954 | 1.00 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL20359956 | 1.00 | NTRK1 (0.43) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL31250788 | 0.94 | NTRK1 (0.44) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18361450 | 0.93 | NTRK1 (0.44) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18361545 | 0.93 | NTRK1 (0.43) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18361487 | 0.92 | MKNK2 (0.38) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL20359267 | 0.92 | NTRK1 (0.45) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL18376029 | 0.92 | NTRK1 (0.45) | NTRK1NTRK3NTRK2MKNK2 | |
| SCHEMBL20359268 | 0.92 | NTRK1 (0.45) | NTRK1NTRK3NTRK2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856192-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | Dana Farber Cancer Institute, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020069106-A1 | DEGRADERS THAT TARGET ALK AND THERAPEUTIC USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-04-02 | — | — | WO | disclosed |