Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.71 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.67 |
| ▸ | OSBP | P22059 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | RORC | P51449 | 1/20 | 0.63 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.56 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | GBA1 | P04062 | 2/20 | 0.55 |
| ▸ | UGCG | Q16739 | 2/20 | 0.55 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.55 |
| ▸ | STS | P08842 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10936315 | 0.99 | POLA1 (0.72) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL23070074 | 0.99 | POLA1 (0.72) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL2050990 | 0.99 | POLA1 (0.72) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL2050989 | 0.99 | POLA1 (0.72) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL7787257 | 0.92 | POLA1 (0.70) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL29055425 | 0.92 | POLA1 (0.70) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL5888346 | 0.92 | POLA1 (0.68) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL7787254 | 0.92 | POLA1 (0.70) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL21177708 | 0.92 | POLA1 (0.70) | POLA1CYP46A1OSBPUSP2LMNA | |
| SCHEMBL5888344 | 0.92 | POLA1 (0.68) | POLA1CYP46A1OSBPUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119185572-A | Ligand-drug conjugate of irinotecan analogue, preparation method and application thereof | 江苏恒瑞医药股份有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-118105513-A | Conjugates comprising self-degrading groups and methods related thereto | 乐高化学生物科学股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| WO-2020063676-A1 | LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 江苏恒瑞医药股份有限公司 | 2020-04-02 | — | — | WO | disclosed |