Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025699 | 0.91 | BRD9 (0.35) | EGFRSMOBRD4BRD9 | |
| SCHEMBL2028548 | 0.86 | NAMPT (0.34) | SMOBRD4BRD9 | |
| SCHEMBL1922118 | 0.86 | NAMPT (0.34) | SMOBRD4BRD9 | |
| SCHEMBL2030372 | 0.86 | NAMPT (0.34) | SMOBRD4BRD9 | |
| SCHEMBL1922408 | 0.86 | JAK3 (0.38) | JAK3JAK2EGFRBTKSYK | |
| SCHEMBL302411 | 0.85 | JAK3 (0.40) | JAK3JAK2EGFRBTKSYK | |
| SCHEMBL2032777 | 0.84 | BRD9 (0.35) | EGFRBTKSMOBRD4BRD9 | |
| SCHEMBL1924064 | 0.80 | NAMPT (0.34) | EGFRBTKBRD4BRD9 | |
| SCHEMBL303148 | 0.79 | JAK2 (0.44) | JAK3JAK2SYKSMOPTGDR2 | |
| SCHEMBL1922278 | 0.79 | AVPR2 (0.32) | BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328871-B1 | HEDGEHOG PATHWAY MODULATORS | NOVARTIS AG (CH) | 2020-04-01 | — | — | EP | disclosed |